About this item Pre-Activated For Superior Absorption - This very powerful B vitamin combination supplies most of the B vitamins in their coenzymated forms, so they are ready for the body to use.* Methyl Folate & Methyl B12 - Includes Quatrefolic folate, which has demonstrated high bioavailability, solubility, and long-lasting stability and. Also includes Vitamin B12 as methylcobalamin. Synergistic Formula - TMG and choline are included to support methylation. B-Supreme also includes the active from of B6 as P-5-P.* Vegan & Non-GMO - This product is Vegetarian and Vegan-Friendly. Made without GMOs, Gluten, Dairy, or Soy. Tinted glass bottles offer a barrier against moisture and oxygen, which helps protect nutrient viability.* Over 50,000 Doctors Agree - Designs for Health is the physician's choice for top quality professional strength supplements since 1989. Our "Science First" philosophy ensures our products are based on the most recent research and use the highest quality raw ingredients.